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The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

《环境科学与工程前沿（英文）》 2015年 第9卷 第6期   页码 1015-1024 doi: 10.1007/s11783-014-0670-0

摘要： The Ecological Footprint (EF), a physical indicator to measure the extent of humanity’s use of natural resources, has gained much attention since it was first used by Wackernagel and Rees in 1996. In order to appraise land area types with different levels of productivity, they introduced the concept of an equivalence factor. This relates to the average primary biomass productivities of different types of land (i.e. arable land, pasture, forest, water/fishery, built-up land and fossil energy land) to the regional average primary biomass productivity of all land types in a given year. Hence, the equivalence factor is an important parameter in the EF model and it directly affects the reliability of all results. Thus, this article calculates equivalence factors on the national and provincial levels in China based on Net Primary Production (NPP) from MODIS 1 km data in 2008. Firstly, based on the Light Utility Efficiency and CASA model, the NPP of different biologically productive lands of China and of different provinces was calculated. Secondly, China’s equivalence factor for 6 land area types was calculated based on NPP: arable land and built-up land has an equivalence factor of 1.71, forest and fossil energy land has a factor of 1.41, pasture has a factor of 0.44 and water/fishery 0.35; Finally, the equivalence factor of 6 land area types in different provinces was also calculated. The NPP of each ecosystem type varies along with the equivalence factor in different provinces. However, the ranking of the equivalence factors in different provinces remain the same, with that of arable land being the largest, and the water/fishery being the smallest.

关键词： ecological footprint     equivalence factor     net primary production     biological capacity     land types    

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通过一个等价雷诺数揭示层流到湍流的转捩区域 Article

陈晓东

《工程（英文）》 2019年 第5卷 第3期   页码 576-579 doi: 10.1016/j.eng.2018.09.013

摘要：

Flow transition from laminar to turbulent mode (and vice versa)—that is, the initiation of turbulence—is one of the most important research subjects in the history of engineering. Even for pipe flow, predicting the onset of turbulence requires sophisticated instrumentation and/or direct numerical simulation, based on observing the instantaneous flow structure formation and evolution. In this work, a local Reynolds number equivalence γ (ratio of local inertia effect to viscous effect) is seen to conform to the Universal Law of the Wall, where γ = 1 represents a quantitative balance between the abovementioned two effects. This coincides with the wall layer thickness (y+ = 1, where y+ is the dimensionless distance from the wall surface defined in the Universal Law of the Wall). It is found that the characteristic of how the local derivative of γ against the local velocity changes with increasing velocity determines the onset of turbulence. For pipe flow, γ ≈ 25, and for plate flow, γ ≈ 151.5. These findings suggest that a certain combination of γ and velocity (nonlinearity) can qualify the source of turbulence (i.e., generate turbulent energy). Similarly, a re-evaluation of the previous findings reveals that only the geometrically narrow domain can act locally as the source of turbulence, with the rest of the flow field largely being left for transporting and dissipating. This understanding will have an impact on the future large-scale modeling of turbulence.

关键词： 局部等价雷诺数     转捩     壁面律     管流     平板流动     建模    

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基于动态等值及数值积分灵敏度的快速紧急控制策略计算 Research Articles

Yi-fan GAO, Jian-quan WANG, Tan-nan XIAO, Dao-zhuo JIANG

《信息与电子工程前沿（英文）》 2019年 第20卷 第8期   页码 1119-1132 doi: 10.1631/FITEE.1700389

摘要： 为减少大规模电力系统暂态稳定分析的计算时间，实现紧急控制策略的实时计算，提出基于实时动态等值的快速暂态稳定仿真及紧急控制策略算法。通过故障后短时间的全系统数值积分计算，将发电组实时分群并进行模型聚合，并运用提出的等值系统节点导纳矩阵快速计算方法求取等值系统网络参数。在获得的动态等值系统上完成暂态稳定仿真计算和基于数值积分灵敏度的紧急控制决策计算。最终，经过等值系统向原始系统反向映射，获得原始系统的紧急控制策略。在包含496台发电机和5075节点的区域电网中进行仿真计算。结果表明该算法可获得准确的暂态稳定计算结果和有效的紧急控制策略，与常规暂态稳定数值积分算法以及基于数值积分灵敏度的紧急控制算法相比，大幅减少了计算时间。

关键词： 紧急控制；暂态稳定；数值积分；动态等值；数值积分灵敏度    

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Experimental evaluation of a 35 kVA downdraft gasifier

Ashok Jayawant Rao KECHE, Gaddale AMBA PRASAD RAO

《能源前沿（英文）》 2013年 第7卷 第3期   页码 300-306 doi: 10.1007/s11708-013-0247-9

摘要： Energy conversion systems based on biomass are particularly interesting because biomass utilization effectively closes the carbon cycle besides achieving self-sustainability. Biomass is particularly useful for highly populated and agriculture dependent economic nations like China and India. A compact and cost effective downdraft gasification system was developed. The present paper describes an experimental investigation on a biomass based gasifier engine system with a capacity of 35 kVA for power generation application. The problem of cooling and cleaning the hot and dirty gas from the gasifier has been satisfactorily solved by the effective cooling and filtration system. The gasifier developed is observed to be operation friendly. The quality of gas was evaluated in terms of its composition, conversion efficiency and total particulate matter. The maximum output of the power plant was obtained at the combustion zone temperature of 850oC. The experimental investigations showed that the percentage reduction in total particulate matter is 89.32%. The conversion efficiency of the biomass gasifier is found to be dependent on the operation conditions and fuel properties of the gasifier. The optimum value of equivalence ratio was observed to be 0.3134 for achieving the maximum gas conversion efficiency of the present gasifier configuration.

关键词： biomass     gasification     producer gas     equivalence ratio     total particulate matter     conversion efficiency of gasifier    

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methane/air mixtures with multiple orifices in a large bore constant volume chamber: effect of air-fuel equivalence

Xiang LI, Wenzheng ZHANG, Zhong HUANG, Dehao JU, Li HUANG, Mingzhi FENG, Xingcai LU, Zhen HUANG

《能源前沿（英文）》 2019年 第13卷 第3期   页码 483-493 doi: 10.1007/s11708-019-0631-1

摘要： Liquefied natural gas (LNG), mainly composed of methane, is in progress to substitute diesel fuel in heavy-duty marine engine for practical, economic, and environmental considerations. However, natural gas is relatively difficult to be ignited in a large bore combustion chamber. A combustion enhancement technique called pre-chamber turbulent jet ignition (TJI) can permit combustion and flame propagation in a large-bore volume. To investigate the effect of air-fuel equivalence ratio and pre-mixed pressure on pre-chamber TJI of methane/air mixtures with multiple orifices in a large bore volume, experimental tests and computational simulations were implemented to study the discharge of hot turbulent jets from six orifices of the pre-chamber. Different initial pressures and air-fuel equivalence ratios were considered to analyze the characteristics of TJI. The asymmetry of the turbulent jet actuated from six different orifices were found due to the asymmetric orientation of the spark plug, resulting in the inhomogeneous distribution of combustion in the constant volume chamber, which should be considered seriously in the marine engine design. Besides, as the premixed pressure increases, it has more effect on the flame propagation and plays a more important role, as it further increases.

关键词： marine engine     natural gas     methane     turbulent jet ignition (TJI)     pre-chamber    

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Numerical analysis and experimental investigation of modal properties for the gearbox in wind turbine

Pengxing YI,Peng HUANG,Tielin SHI

《机械工程前沿（英文）》 2016年 第11卷 第4期   页码 388-402 doi: 10.1007/s11465-016-0404-z

摘要：

Wind turbine gearbox (WTG), which functions as an accelerator, ensures the performance and service life of wind turbine systems. This paper examines the distinctive modal properties of WTGs through finite element (FE) and experimental modal analyses. The study is performed in two parts. First, a whole system model is developed to investigate the first 10 modal frequencies and mode shapes of WTG using flexible multi-body modeling techniques. Given the complex structure and operating conditions of WTG, this study applies spring elements to the model and quantifies how the bearings and gear pair interactions affect the dynamic characteristics of WTGs. Second, the FE modal results are validated through experimental modal analyses of a 1.5 WM WTG using the frequency response function method of single point excitation and multi-point response. The natural frequencies from the FE and experimental modal analyses show favorable agreement and reveal that the characteristic frequency of the studied gearbox avoids its eigen-frequency very well.

关键词： wind turbine gearbox     modal analysis     finite element analysis     modal frequency     bearing equivalence    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 376-380 doi: 10.1007/s11684-012-0228-0

摘要：

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

关键词： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

《结构与土木工程前沿（英文）》 2022年 第16卷 第7期   页码 871-881 doi: 10.1007/s11709-022-0863-8

摘要： The failure criteria of practical soil mass are very complex, and have significant influence on the safety factor of slope stability. The Coulomb strength criterion and the power-law failure criterion are classically simplified. Each one has limited applicability owing to the noticeable difference between calculated predictions and actual results in some cases. In the work reported here, an analysis method based on the least square support vector machine (LSSVM), a machine learning model, is purposefully provided to establish a complex nonlinear failure criterion via iteration computation based on strength test data of the soil, which is of more extensive applicability to many problems of slope stability. In particular, three evaluation indexes including coefficient of determination, mean absolute percentage error, and mean square error indicate that fitting precision of the machine learning-based failure criterion is better than those of the linear Coulomb criterion and nonlinear power-law criterion. Based on the proposed LSSVM approach to determine the failure criterion, the limit equilibrium method can be used to calculate the safety factor of three-dimensional slope stability. Analysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum relative errors between the proposed approach and the linear failure criterion-based method and the power-law failure criterion-based method are about 12% and 7%, respectively.

关键词： slope stability     safety factor     failure criterion     least square support vector machine    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

《医学前沿（英文）》 2023年 第17卷 第2期   页码 317-329 doi: 10.1007/s11684-022-0931-4

摘要： Long noncoding RNAs (lncRNAs) play a critical role in the regulation of atherosclerosis. Here, we investigated the role of the lncRNA growth arrest-specific 5 (lncR-GAS5) in atherogenesis. We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis, which presented as increased plaque size and reduced collagen content. Moreover, impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells. By contrast, lncR-GAS5 knockdown promoted autophagy. Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3I ratio and decreased the P62 level, thus enhancing the formation of autophagic vacuoles, autolysosomes, and autophagosomes. Mechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium, which was reversed by the knockdown of SRSF10. Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene, SRSF10. Notably, miR-193-5p overexpression decreased plaque size and increased collagen content. Altogether, these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy. In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway. Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

关键词： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 877-894 doi: 10.1007/s11709-021-0756-2

摘要： Many bridge design specifications consider multi-lane factors (MLFs) a critical component of the traffic load model. Measured multi-lane traffic data generally exhibit significant lane disparities in traffic loads over multiple lanes. However, these disparities are not considered in current specifications. To address this drawback, a multi-coefficient MLF model was developed based on an improved probabilistic statistical approach that considers the presence of multiple trucks. The proposed MLF model and approach were calibrated and demonstrated through an example site. The model sensitivity analysis demonstrated the significant influence of lane disparity of truck traffic volume and truck weight distribution on the MLF. Using the proposed approach, the experimental site study yielded MLFs comparable with those directly calculated using traffic load effects. The exclusion of overloaded trucks caused the proposed approach, existing design specifications, and conventional approach of ignoring lane load disparity to generate comparable MLFs, while the MLFs based on the proposed approach were the most comprehensive. The inclusion of overloaded trucks caused the conventional approach and design specifications to overestimate the MLFs significantly. Finally, the benefits of the research results to bridge practitioners were discussed.

关键词： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion data    

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Numerical investigation of the influence of kinetics and shape factor on barium sulfate precipitation

Zheng WANG, Zai-Sha MAO, Chao YANG, Qinghua ZHANG, Jingcai CHENG

《化学科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 272-281 doi: 10.1007/s11705-009-0023-x

摘要： The effect of kinetics and shape factor on barium sulfate precipitation in a continuous stirred tank has been investigated numerically through solving the standard momentum and mass transport equations in combination with the moment equations for crystal population balance. The numerical method was validated with the literature data. The simulated results include the distribution of the local supersaturation ratio in the reactor, the mean crystal size, and the coefficient of variation. The simulation results show that the value of shape factor used in the model affected greatly the mean crystal size and the moments of the crystal size distribution. The influence of the kinetic expressions on the simulation is also analyzed. It is important to investigate the relationship of the shape factor with the precipitator type and other operation conditions to obtain reliable simulation results and suitable kinetic equations of crystal nucleation and growth rates.

关键词： stirred tank     numerical simulation     precipitation     shape factor     crystal kinetics    

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The formation mechanism and the influence factor of residual stress in machining

null

《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 265-269 doi: 10.1007/s11465-014-0311-0

摘要：

Residual stresses generated in cutting process have important influences on workpiece performance. The paper presents a method of theoretical analysis in order to explicate the formation mechanism of residual stresses in cutting. An important conclusion is drawn that the accumulated plastic strain is the main factor which determines the nature and the magnitude of surface residual stresses in the workpiece. On the basis of the analytical model for residual stress, a series of simulations for residual stress prediction during cutting AISI 1045 steel are implemented in order to obtain the influences of cutting speed, depth of cut and tool edge radius on surface residual stress in the workpiece. And these influences are explained from the perspective of formation mechanism of residual stress in cutting. The conclusions have good applicability and can be used to guide the parameters selection in actual production.

关键词： residual stress     analytical model     strain     plastic     cutting parameter    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 403-409 doi: 10.1007/s11684-017-0522-y

摘要：

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.

关键词： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle cells    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 25-30 doi: 10.1007/s11684-013-0244-8

摘要：

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.

关键词： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

null

《医学前沿（英文）》 2015年 第9卷 第1期   页码 90-99 doi: 10.1007/s11684-015-0390-2

摘要：

Gene therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directed gene transfer mediated by adeno-associated viral vectors. Recent clinical trials involving the use of a self-complementary adeno-associated virus serotype 8-human codon-optimized factor IX (AAV8-hFIXco) vector demonstrated encouraging efficacy with hFIX expression stabilized at 1% to 6% of normal level in patients, but safety concerns related to high vector doses are still present. Thus, further improvement of AAV vectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B gene therapy. In this study, to obtain a higher expression level of hFIX that potentiates the coagulant capacity of recipients, human FIX expression vector was optimized by upgrading the codon adaption index and adjusting the GC content, inserting a Kozak sequence (GCCACC), and introducing a gain-of-function mutation, R338L (FIX Padua). The efficiency of the published and the presently constructed cassettes was compared through in vivo screening. In addition, the regulatory elements that control the FIX gene expression in these cassettes were screened for liver-specific effectiveness. Among all the constructed cassettes, scAAV-Pre-hFIXco-SIH-R338L, which was the construct under the control of the prothrombin enhancer and prealbumin promoter, resulted in the highest level of coagulant activity, and the expression levels of two constructed cassettes (scAAV-Chi-hFIXco-SIH-R338L and scAAV-Pre-hFIXco-SIH-R338L) were also higher than that of the published cassette (scAAV-LP1-hFIXco-SJ). In summary, our strategies led to a substantial increase in hFIX expression at the protein level or a remarkably elevated coagulant activity. Thus, these reconstructs of hFIX with AAV vector may potentially contribute to the creation of an efficacious gene therapy of hemophilia B.

关键词： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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标题 作者 时间 类型 操作

The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

期刊论文

通过一个等价雷诺数揭示层流到湍流的转捩区域

陈晓东

期刊论文

基于动态等值及数值积分灵敏度的快速紧急控制策略计算

Yi-fan GAO, Jian-quan WANG, Tan-nan XIAO, Dao-zhuo JIANG

期刊论文

Experimental evaluation of a 35 kVA downdraft gasifier

Ashok Jayawant Rao KECHE, Gaddale AMBA PRASAD RAO

期刊论文

methane/air mixtures with multiple orifices in a large bore constant volume chamber: effect of air-fuel equivalence

Xiang LI, Wenzheng ZHANG, Zhong HUANG, Dehao JU, Li HUANG, Mingzhi FENG, Xingcai LU, Zhen HUANG

期刊论文

Numerical analysis and experimental investigation of modal properties for the gearbox in wind turbine

Pengxing YI,Peng HUANG,Tielin SHI

期刊论文

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

null

期刊论文

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

期刊论文

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

期刊论文

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

期刊论文

Numerical investigation of the influence of kinetics and shape factor on barium sulfate precipitation

Zheng WANG, Zai-Sha MAO, Chao YANG, Qinghua ZHANG, Jingcai CHENG

期刊论文

The formation mechanism and the influence factor of residual stress in machining

null

期刊论文

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

期刊论文

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

期刊论文

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

null

期刊论文